Antibiogram 2026

2025 isolates. Ronald Reagan and Santa Monica data; West Valley is outpatient only.

Full antibiogram (PDF) ↓

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Gram-negatives↓MDR organisms↓MRSA and VRE↓Yeasts↓

% susceptible

 ≥90 80–89 70–79 60–69 <60

Darker means more resistant.

  • Tobramycin is the aminoglycoside of choice for Pseudomonas aeruginosa.
  • In sepsis without culture data, use tobramycin, not gentamicin or amikacin.

Why: tobramycin is the most active aminoglycoside against P. aeruginosa and the only one with CLSI breakpoints for systemic infection (2023). Gentamicin has none; amikacin’s apply to urine only.

Susceptibility by organism

Gram-negatives, most active agents first

96Blue ring: preferred empiric regimen

SDD: covered only at the higher CLSI dose, so standard-dose coverage is lower than shown

ID consultCall ID first

Adults non-urine

Read down a column to compare care settings

Enterobacter cloacae complex
Outpatientn=91
98Levofloxacin
97Ciprofloxacin
96TMP-SMX
Inpatientn=102
100Meropenem
99CefepimeSDD
91Ciprofloxacin
91Levofloxacin
90Ertapenem
ICUn=65
98Ciprofloxacin
97Meropenem
97Levofloxacin
95CefepimeSDD
94Ertapenem
Escherichia coli
Outpatientn=452
69Amoxicillin-clavulanate
68Levofloxacin
65Ciprofloxacin
62TMP-SMX
56Oral cephalosporin
Inpatientn=506
99Ertapenem
99Meropenem
95Piperacillin-tazobactamSDD
78CefepimeSDD
71Ceftazidime
ICUn=130
100Meropenem
98Ertapenem
89Piperacillin-tazobactamSDD
72CefepimeSDD
62Ceftazidime
Klebsiella pneumoniae
Outpatientn=198
89Levofloxacin
87Amoxicillin-clavulanate
77Ciprofloxacin
74Oral cephalosporin
74TMP-SMX
Inpatientn=243
98Meropenem
97Ertapenem
90Piperacillin-tazobactamSDD
82Levofloxacin
81CefepimeSDD
ICUn=132
94Ertapenem
94Meropenem
81Piperacillin-tazobactamSDD
78Levofloxacin
73CefepimeSDD
Proteus mirabilis
Outpatientn=169
93Amoxicillin-clavulanate
78Ciprofloxacin
78Levofloxacin
74TMP-SMX
22Oral cephalosporin
Inpatientn=162
100Ertapenem
100Meropenem
98Piperacillin-tazobactamSDD
98Ceftazidime
96CefepimeSDD
ICUn=29 · small
97Ertapenem
97Meropenem
93Piperacillin-tazobactamSDD
93Ceftazidime
90CefepimeSDD
Pseudomonas aeruginosa
Outpatientn=533
81Ciprofloxacin
78Levofloxacin
Inpatientn=446
90CefepimeSDD
85Ceftazidime
85Meropenem
81Piperacillin-tazobactamSDD
80Ciprofloxacin
ICUn=142ID consult
77CefepimeSDD
74Ciprofloxacin
73Ceftazidime
68Meropenem
66Levofloxacin

Adults other gram-negatives

Non-urine, pooled across care settings

Achromobacter spp.n=78
95TMP-SMX
91Meropenem
88Piperacillin-tazobactam
62Ceftazidime
55Levofloxacin
Acinetobacter baumannii complexn=80ID consult
68TMP-SMX
60Levofloxacin
56Ciprofloxacin
55CefepimeSDD
55Meropenem
Citrobacter freundii complexn=103
99Meropenem
97Ertapenem
96CefepimeSDD
90Levofloxacin
89Ciprofloxacin
Klebsiella (Enterobacter) aerogenesn=100
98CefepimeSDD
98Meropenem
98TMP-SMX
96Ertapenem
96Levofloxacin
Klebsiella oxytocan=206
99Ertapenem
99Meropenem
97CefepimeSDD
97Levofloxacin
96Piperacillin-tazobactam
Morganella morganiin=83
100Piperacillin-tazobactam
100CefepimeSDD
99Ertapenem
99Meropenem
89Ceftazidime
Serratia marcescensn=226
100CefepimeSDD
100Meropenem
99Ertapenem
99TMP-SMX
98Ceftazidime
Stenotrophomonas maltophilian=111ID consult

No routinely reported agent. See MDR organisms for salvage agents.

Adults urine

Urinary isolates only

Enterobacter cloacae complex
Outpatientn=236
93Ciprofloxacin
92Levofloxacin
90TMP-SMX
51Nitrofurantoin
Inpatientn=52
99CefepimeSDD
99Meropenem
88Ciprofloxacin
88Levofloxacin
87Ertapenem
Escherichia coli
Outpatientn=9692
97Nitrofurantoin
87Amoxicillin-clavulanate
86Oral cephalosporin
74TMP-SMX
71Levofloxacin
Inpatientn=1094
99Ertapenem
99Meropenem
96Nitrofurantoin
80Amoxicillin-clavulanate
74Ceftriaxone
Klebsiella pneumoniae
Outpatientn=1657
87Oral cephalosporin
86TMP-SMX
84Ciprofloxacin
84Levofloxacin
32Nitrofurantoin
Inpatientn=291
99Ertapenem
99Meropenem
78Ceftriaxone
78TMP-SMX
77Oral cephalosporin
Proteus mirabilis
Outpatientn=944
97Amoxicillin-clavulanate
94Oral cephalosporin
88Ciprofloxacin
88Levofloxacin
82TMP-SMX
Inpatientn=189
99Ertapenem
99Meropenem
93Amoxicillin-clavulanate
82Ceftriaxone
78Oral cephalosporin
Pseudomonas aeruginosa
Outpatientn=490
89Ciprofloxacin
84Levofloxacin
Inpatientn=143
89CefepimeSDD
88Meropenem
85Ceftazidime
85Ciprofloxacin
83Piperacillin-tazobactamSDD

Pediatrics non-urine

21 years and under, pooled across care settings

Enterobacter cloacae complexn=29 · small
99Ertapenem
99Meropenem
97Cefepime
96TMP-SMX
93Ciprofloxacin
Escherichia colin=68
99Ertapenem
99Meropenem
94Piperacillin-tazobactam
90Cefepime
88Ceftazidime
Klebsiella pneumoniaen=42
99Meropenem
95Ertapenem
90Piperacillin-tazobactam
90Cefepime
86Ceftazidime
Serratia marcescensn=35
99Piperacillin-tazobactam
99Cefepime
99Ertapenem
99Meropenem
97TMP-SMX
Pseudomonas aeruginosan=94
95Cefepime
94Ceftazidime
93Piperacillin-tazobactam
90Meropenem
89Ciprofloxacin

Pediatrics urine

21 years and under, urinary isolates only

Enterobacter cloacae complexn=24 · small
99Cefepime
99Meropenem
92Ciprofloxacin
91Ertapenem
83TMP-SMX
Escherichia colin=904
99Ertapenem
99Meropenem
98Nitrofurantoin
93Ceftriaxone
91Oral cephalosporin
Klebsiella pneumoniaen=95
99Ertapenem
99Meropenem
91Amoxicillin-clavulanate
88Ceftriaxone
87Oral cephalosporin
Proteus mirabilisn=123
99Oral cephalosporin
99Ceftriaxone
99Ertapenem
99Meropenem
97Ciprofloxacin
Pseudomonas aeruginosan=14 · small
99Cefepime
99Ceftazidime
99Meropenem
93Ciprofloxacin

Multidrug-resistant organisms

Gram-negative salvage agents, all sources

Most of these agents are restricted formulary. Ceftazidime-avibactam, ceftolozane-tazobactam, meropenem-vaborbactam, cefiderocol, minocycline IV, tigecycline, eravacycline and omadacycline are released by pharmacy only with Infectious Diseases approval. Call ID when you send the culture, not after the result returns.

Scroll the table sideways to see every agent.

Organism
Amikacin
Gentamicin
Ciprofloxacin
Piperacillin-tazobactam
Cefepime
Ceftazidime
Ceftazidime-avibactam †
Ceftolozane-tazobactam †
Meropenem-vaborbactam †
Minocycline †
TMP-SMX
Tigecycline ‡
Eravacycline † ‡
Omadacycline ‡
Carbapenem-resistant Enterobacterales (CRE)n=349
83n=349
–
–
–
–
–
94n=349
77n=349
77n=66
–
–
87n=70
79n=66
80n=66
P. aeruginosa — imipenem OR meropenem resistantn=292
91*n=292
–
50n=292
49n=292
63n=292
59n=292
90n=292
91n=292
–
R
R
–
–
–
P. aeruginosa — imipenem AND meropenem resistantn=171
89*n=171
–
38n=171
29n=171
47n=171
41n=171
87n=171
89n=171
–
R
R
–
–
–
A. baumannii complex — meropenem resistantn=42
43n=42
21n=42
10n=42
2n=42
2n=42
5n=42
–
–
–
50n=42
36n=42
–
–
–

†Restricted formulary: ID approval needed.

‡FDA breakpoints (no CLSI breakpoints). Not for bacteremia.

*Amikacin for P. aeruginosa: urine isolates only.

Rintrinsically resistant; – not reported. CRE denominators differ by agent.

MRSA and VRE

Gram-positive cocci, % resistant

Adults

S. aureus · Outpatient

24%MRSA

  n=1886
S. aureus · Inpatient

36%MRSA

  n=830
S. aureus · ICU

35%MRSA

  n=236
E. faecalis

4%VRE

  n=683
E. faecium

60%VRE

  n=223
Enterococcus spp. (other)

42%VRE

  n=48

Pediatrics

21 years and under

S. aureus · Outpatient

12%MRSA

  n=538
S. aureus · Inpatient

13%MRSA

  n=113
E. faecalis

1%VRE

  n=43
E. faecium

40%VRE

  n=5 · small

Resistance rates only. Full gram-positive susceptibility tables are in the PDF.

Yeasts

Breakpoints in µg/mL

UCLA Stewardship: start empiric fluconazole in clinically stable patients when BCID or culture identifies C. albicans, C. parapsilosis or C. tropicalis.

Candida albicansn=344Fluconazole preferred

Fluconazole

  
S 96% ≤2R 4% ≥8

Micafungin

 
S 99% ≤0.25
Candida glabratan=207

Fluconazole

  
SDD 87% <32R 13% ≥64

Micafungin

  
S 99% ≤0.06I 1% 0.12
Candida parapsilosisn=86Fluconazole preferred

Fluconazole

  
S 95% ≤2R 5% ≥8

Micafungin

 
S 99% ≤2
Candida tropicalisn=57Fluconazole preferred

Fluconazole

  
S 96% ≤2R 4% ≥8

Micafungin

 
S 99% ≤0.25
Candida krusein=34

Fluconazole

Intrinsically resistant to fluconazole.

Micafungin

 
S 99% ≤0.25
Candida guilliermondiin=10

Fluconazole

No interpretable result

Micafungin

 
S 99% ≤2

2024–2025 isolates. Not all isolates were tested against all agents.